Here is an interesting look into modern research on hangover cures. A study from Sun Yat-sen University provides a great example of how scientists are analyzing the biochemical processes behind hangovers and exploring potential remedies. By focusing on how certain substances interact with the enzymes involved in alcohol metabolism—like acetaldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH)—they’ve been able to pinpoint specific drinks that might help or hinder recovery.
The herbal infusion "Huo ma ren" (made from hemp seeds) increasing ADH levels makes sense from a metabolic standpoint. ADH helps to break down ethanol into acetaldehyde, which is then further broken down by ALDH into acetate. The researchers' finding that it accelerates alcohol breakdown is interesting because it could theoretically reduce some of the negative effects of alcohol's toxic byproducts, which are largely responsible for hangover symptoms.
However, the fact that "Huo ma ren" inhibits ALDH, the enzyme responsible for getting rid of acetate, is a bit of a double-edged sword. While it might speed up the first phase of alcohol metabolism, the accumulation of acetate could be problematic. Acetate, though less toxic than acetaldehyde, can still contribute to symptoms like headache, fatigue, and nausea, which are common in hangovers.
As for green tea, it’s fascinating (and somewhat counterintuitive) that the antioxidants in it might interfere with alcohol metabolism. Green tea is widely recognized for its health benefits, but the compounds in it—such as catechins—can interact with enzymes in ways that slow down the breakdown of alcohol, potentially making hangover recovery slower if consumed during or after drinking.
This study highlights the complexity of hangovers and how different remedies or substances can have opposing effects, sometimes helping in one aspect while hindering another. It also points to the need for further research to fully understand which compounds or drinks might have the most positive effect on hangover recovery without causing additional problems in the body’s processing of alcohol.
Can science help defeat the physical aftereffects of drinking too much alcohol—if not the regrets? Here is an old and tried recommendation.
https://www.thekitchn.com/penicillin-cocktail-recipe-23620966
https://www.scientificamerican.com/article/in-search-of-a-cure-for-the-…
https://www.thekitchn.com/penicillin-cocktail-recipe-review-23690864