Margarita was a bright and beautiful school teacher, who didn’t speak English fluently, but she sure was funny.
I recall her story when she landed her first job and was asked to write reports, her boss called them ‘Funny Papers”
As with any daily strip, the "best" Calvin and Hobbes is largely an exercise left up to the individual reader.
American culture as a whole really does have a problem with accepting and measuring intangibles. It took much of the rest of pop culture over 30 years to catch up to Watterson here, but you can see similar messages sneaking into the mainstream now, such as the unsubtle vein of villainous capitalism that runs through much of Al Ewing's work at Marvel. If something isn't making fat stacks of shareholder cash right now, then there are tech dorks lining up to denounce them as unnecessary. Those dorks are always wrong, but even the ensuing damage isn't enough to convince them of that.
Ask any 10 fans and you're likely to get 11 answers, none of which are untrue or invalid. When everyone who was willing to cite a specific favorite strip or quotation from Calvin and Hobbes brought up a different one…